Structure of PDB 8ove Chain Bf

Receptor sequence

>8oveBf (length=400) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]

SHCKFEHPRHGHLGFLPRKRSRQIRGRARSFPKDDPSQKPHLTSFMVYKA
GMTHIVRDVDRPGSKVNKKEVVEPVTILEAPPMVVVGIVGYRQTPVGHKT
IGTVWAHHTSVEFRRRFYKNWKQSAQLAFTKRKQFARTTEGRLAEARTLK
AFEKKADIIRVVAHTQLRKLRNNRVGVKKAHVSEIQINGGTIAQKIELAK
SLLEKEVRIDSVFQQSEACDVCAVTKGHGFTGVVKRWGVACLPRKTHRGL
RKVACIGAWHPSRVMYTVARAGQHGYHHRTHLNKKIYQLGRAVSMEPNQA
TTAYDLTAKTITPMGGFVGYGTVRNDYVMLKGSVAGPRRRVITLRRPMAP
QTSRKLTEKITLKFIDTSSKIGHGRFQTKKEKSQWYGPLKKDRIRREERL

3D structure

PDB

8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	Bf	K246 H248	K245 H247
BS02	rna	Bf	S2 H3 C4 K5 E7 R10 H11 P18 R19 K20 R21 R93 H109 Q135 R138 T139 R148 K151 K170 E207 R209 F231 G233 R237 K246 T247 H248 R249 G250 L251 R252 A255 C256 I257 A259 W260 H261 S263 R264 V265 T268 R271 A272 Q274 N326 D327	S1 H2 C3 K4 E6 R9 H10 P17 R18 K19 R20 R92 H108 Q134 R137 T138 R147 K150 K169 E206 R208 F230 G232 R236 K245 T246 H247 R248 G249 L250 R251 A254 C255 I256 A258 W259 H260 S262 R263 V264 T267 R270 A271 Q273 N325 D326
BS03	rna	Bf	G12 H13 L14 G15 F16 P18 R26 R30 S31 K50 M53 T54 H55 S65 P75 Y92 H99 T101 W106 F118 L128 F130 K132 R133 R161 E185 T226 K227 H279 R280 H282 L283 S334 V335 R355 G373 H374	G11 H12 L13 G14 F15 P17 R25 R29 S30 K49 M52 T53 H54 S64 P74 Y91 H98 T100 W105 F117 L127 F129 K131 R132 R160 E184 T225 K226 H278 R279 H281 L282 S333 V334 R354 G372 H373
BS04	rna	Bf	R21 I25 R117 K120 N121 K123 Q124 N174 R175 G177 V178 K179 K180 K227 G228 G230 F231 Y277 M315 G316 G320 R325 R340 R341 S370 I372 K380 K383 W386 Y387 K391	R20 I24 R116 K119 N120 K122 Q123 N173 R174 G176 V177 K178 K179 K226 G227 G229 F230 Y276 M314 G315 G319 R324 R339 R340 S369 I371 K379 K382 W385 Y386 K390

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005762	mitochondrial large ribosomal subunit
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum	8ove
PubMed	37985661
UniProt	Q581Q1

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