Structure of PDB 8ova Chain Bf

Receptor sequence

>8ovaBf (length=396) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence]

SHCKFEHPRHGHLGFLPRKRSRQIRGRARSFPKDDPSQKPHLTSFMVYKA
GMTHIVRDVDRPGSKVNKKEVVEPVTILEAPPMVVVGIVGYRQTPVGHKT
IGTVWAHHTSVEFRRRFYKNWKQSAQLAFTKRKQFARTTEGRLAEARTLK
AFEKKADIIRVVAHTQLRKLRNNRVGVKKAHVSEIQINGGTIAQKIELAK
SLLEKEVRIDSVFQQSEACDVCAVTKGHGFTGVVKRWGVACLPRKTHRGL
RKVACIGAWHPSRVMYTVARAGQHGYHHRTHLNKKIYQLGRAVSMEPNQA
TTAYDLTAKTITPMGGFVGYGTVRNDYVMLKGSVAGPRRRVITLRRPMAP
QTSRKLTEKITLKFIDTSSKIGHGRFQTKKEKSQWYGPLKKDRIRR

3D structure

PDB

8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.

Chain

Resolution

2.47 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	Bf	K246 H248	K245 H247
BS02	rna	Bf	S2 H3 K5 E7 H8 P9 R10 H11 P18 R19 K20 R21 P83 R93 H109 Q135 R138 T139 R148 K151 R169 E207 R209 F231 G233 R237 K246 T247 H248 R249 G250 R252 A255 C256 G258 A259 W260 H261 S263 R264 V265 M266 T268 R271 A272 Q274 M296 N326 D327	S1 H2 K4 E6 H7 P8 R9 H10 P17 R18 K19 R20 P82 R92 H108 Q134 R137 T138 R147 K150 R168 E206 R208 F230 G232 R236 K245 T246 H247 R248 G249 R251 A254 C255 G257 A258 W259 H260 S262 R263 V264 M265 T267 R270 A271 Q273 M295 N325 D326
BS03	rna	Bf	R21 R116 R117 K120 N121 K123 Q124 R172 N174 R175 G177 V178 K179 K180 G228 G230 F231 Y277 M315 G316 G320 G322 R325 R340 R341 S370 I372 K380 K383 Y387 K391 R394 R396	R20 R115 R116 K119 N120 K122 Q123 R171 N173 R174 G176 V177 K178 K179 G227 G229 F230 Y276 M314 G315 G319 G321 R324 R339 R340 S369 I371 K379 K382 Y386 K390 R393 R395
BS04	rna	Bf	G12 H13 L14 G15 P18 K20 R26 R30 S31 M53 T54 H55 S65 P75 Y92 H99 T101 W106 F118 L128 A129 F130 K132 R133 E185 T226 K227 K236 H279 R280 L283 S334 V335 R346 A350 R355 K356 G373	G11 H12 L13 G14 P17 K19 R25 R29 S30 M52 T53 H54 S64 P74 Y91 H98 T100 W105 F117 L127 A128 F129 K131 R132 E184 T225 K226 K235 H278 R279 L282 S333 V334 R345 A349 R354 K355 G372

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005762	mitochondrial large ribosomal subunit
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum	8ova
PubMed	37985661
UniProt	Q581Q1

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