Structure of PDB 4v7d Chain BZ

Receptor sequence

>4v7dBZ (length=686) Species: 83333 (Escherichia coli K-12)

TTPIARYRNIGISAHIDAGKTTTTERILFYTGGEVHDGAATEQERGITIT
SAATTAFWSGMAKQYEPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYC
AVGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANFLKVVNQIKTRLGA
NPVPLQLAIGAEEHFTGVVDLVKMKAINWNDADQGVTFEYEDIPADMVEL
ANEWHQNLIESAAEASEELMEKYLGGEELTEAEIKGALRQRVLNNEIILV
TCGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILDDGKDTPAERHASDD
EPFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKAARERFGRIV
QMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDPDAPIILERMEFPEP
VISIAVEPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGEL
HLDIIVDRMKREFNVEANVGKPQVAYRETIRQKVTDVEGKHAKQSGGRGQ
YGHVVIDMYPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQLKAG
PLAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLE
PIMKVEVETPEENTGDVIGDLSRRRGMLKGQESEVTGVKIHAEVPLSEMF
GYATQLRSLTKGRASYTMEFLKYDEAPSNVAQAVIE

3D structure

• PDB: 4v7d Structure of the ribosome with elongation factor G trapped in the pretranslocation state.
• Chain: BZ
• Resolution: 7.6 Å

Enzymatic activity

• Enzyme Commision number: 3.6.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	BZ	D20 E56 R146 F270 E463 L464 I632 R637 M641 L642 Q645 K675	D17 E42 R132 F256 E449 L450 I618 R623 M627 L628 Q631 K661
BS02	rna	BZ	G41 D45 A48 T49 F329 V330 R359 R362 E373 I386 K389 G510 G511 R512 Q514 Y583 H584 D585 V586 S589 L591	G33 D37 A40 T41 F315 V316 R345 R348 E359 I372 K375 G496 G497 R498 Q500 Y569 H570 D571 V572 S575 L577

Gene Ontology

Molecular Function

• GO:0003746 translation elongation factor activity
• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0097216 guanosine tetraphosphate binding

Biological Process

• GO:0006412 translation
• GO:0006414 translational elongation
• GO:0032790 ribosome disassembly

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4v7d, PDBe:4v7d, PDBj:4v7d
• PDBsum: 4v7d
• PubMed: 24324137
• UniProt: P0A6M8|EFG_ECOLI Elongation factor G (Gene Name=fusA)