Structure of PDB 6olz Chain BS

Receptor sequence

>6olzBS (length=139) Species: 9606 (Homo sapiens) [Search protein sequence]

VIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLT
KRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGL
DNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRR

3D structure

PDB

6olz Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.

Chain

Resolution

3.9 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	BS	E112 K115 K116 R118	E109 K112 K113 R115
BS02	rna	BS	R24 K25 F28 G35 V36 G37 R38 R39 Y40 R55 W82 F83 N85 R86 Q87 K88 D89 D110 H120 R121 V131 R132 Q134 H135 T136 K137 R141 R142	R21 K22 F25 G32 V33 G34 R35 R36 Y37 R52 W79 F80 N82 R83 Q84 K85 D86 D107 H117 R118 V128 R129 Q131 H132 T133 K134 R138 R139

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0019843	rRNA binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0014069	postsynaptic density
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:6olz, PDBe:6olz, PDBj:6olz
PDBsum	6olz
PubMed	31160784
UniProt	P62269\|RS18_HUMAN Small ribosomal subunit protein uS13 (Gene Name=RPS18)