Structure of PDB 4v9a Chain BR

Receptor sequence

>4v9aBR (length=137) Species: 300852 (Thermus thermophilus HB8)

MNRGALIKLVESRYVRTDLPEFRPGDTVRVSYKVKEGNRTRIQDFEGIVI
RIRRNGFNTTFTVRKVSYGVGVERIFPLHSPLIQKIDIVQRGRARRAKLY
FIRNLSDREIRRKLRADRKRIDQDRAAERAAKEEAQK

3D structure

• PDB: 4v9a Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis.
• Chain: BR
• Resolution: 3.2999 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	BR	E36 R39 R41 D107 R108 R118 K119 D122 R125	E36 R39 R41 D107 R108 R118 K119 D122 R125
BS02	rna	BR	N2 R3 A5 L6 R23 R51 R53 R54 G56 N58 T60 I75 R93 R95 R96 A97 K98 Y100 F101 K113 K119	N2 R3 A5 L6 R23 R51 R53 R54 G56 N58 T60 I75 R93 R95 R96 A97 K98 Y100 F101 K113 K119

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v9a, PDBe:4v9a, PDBj:4v9a
• PDBsum: 4v9a
• PubMed: 23431179
• UniProt: P60490|RL19_THET8 Large ribosomal subunit protein bL19 (Gene Name=rplS)