Structure of PDB 4u25 Chain BP

Receptor sequence
>4u25BP (length=114) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
SNIIKQLEQEQMKQDVPSFRPGDTVEVKVWVVEGSKKRLQAFEGVVIAIR
NRGLHSAFTVRKISNGEGVERVFQTHSPVVDSISVKRRGAVRKAKLYYLR
ERTGKAARIKERLN
3D structure
PDB4u25 Synergy of streptogramin antibiotics occurs independently of their effects on translation.
ChainBP
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna BP E34 S36 K37 K106 R109 L114 E33 S35 K36 K105 R108 L113
BS02 rna BP S2 N3 R21 R51 N52 R53 H56 Q75 R93 K94 A95 K96 Y98 Y99 R103 S1 N2 R20 R50 N51 R52 H55 Q74 R92 K93 A94 K95 Y97 Y98 R102
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Cellular Component
External links
PDB RCSB:4u25, PDBe:4u25, PDBj:4u25
PDBsum4u25
PubMed24957822
UniProtP0A7K6|RL19_ECOLI Large ribosomal subunit protein bL19 (Gene Name=rplS)

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