Structure of PDB 4v6u Chain BO

Receptor sequence

>4v6uBO (length=197) Species: 186497 (Pyrococcus furiosus DSM 3638)

MAHGPRYRVPFRRRREGKTNYRKRLKLLKSGKPRLVVRKSLNHHIAQIIV
YDPKGDRTLVSAHTRELIRDFGWKGHCGNTPSAYLLGLLIGYKAKQAGIE
EAILDIGLHPPVRGSSVFAVLKGAVDAGLNVPHSPEIFPDEYRIRGEHIA
EYAKMLKEQDEEKFRRQFGGYLVKGLDPEKLPEHFEEVKARIIEKFE

3D structure

• PDB: 4v6u Promiscuous behaviour of archaeal ribosomal proteins: Implications for eukaryotic ribosome evolution.
• Chain: BO
• Resolution: 6.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	BO	M1 A2 R6 Y7 R8 R13 R14 G17 K18 N20 R22 L27 K29 S30 I103 P110 P111 P132 S134 I137	M1 A2 R6 Y7 R8 R13 R14 G17 K18 N20 R22 L27 K29 S30 I103 P110 P111 P132 S134 I137
BS02	rna	BO	M1 H3 G4 V9 F11 R12 R13 R15 K18 Y21 R24 R38 S40 L41 N42 H43 Q47 I49 P53 K54 G55 D56 T58 S61 E66 R69 H76 N79 T80 H109 P110 R113 G114 S116 R143 H148 I149 Y152 F168 L172 V173 K174	M1 H3 G4 V9 F11 R12 R13 R15 K18 Y21 R24 R38 S40 L41 N42 H43 Q47 I49 P53 K54 G55 D56 T58 S61 E66 R69 H76 N79 T80 H109 P110 R113 G114 S116 R143 H148 I149 Y152 F168 L172 V173 K174

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v6u, PDBe:4v6u, PDBj:4v6u
• PDBsum: 4v6u
• PubMed: 23222135
• UniProt: Q9HH80|RL18_PYRFU Large ribosomal subunit protein uL18 (Gene Name=rpl18)