Structure of PDB 4u27 Chain BO

Receptor sequence

>4u27BO (length=116) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

DKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAA
STVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHG
RVQALADAAREAGLQF

3D structure

PDB

4u27 Synergy of streptogramin antibiotics occurs independently of their effects on translation.

Chain

Resolution

2.8 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	BO	R9 R10 T12 R13 R16 K17 L18 L21 S91 R94 Q98 Y99 R111 F117	R8 R9 T11 R12 R15 K16 L17 L20 S90 R93 Q97 Y98 R110 F116
BS02	rna	BO	K3 R15 R25 H29 R30 T31 P32 R33 H34 Y36 Q38 I40 G44 S45 E46 V47 V54 E55 K63 Y64 N67 K68 Q98 H100 R102	K2 R14 R24 H28 R29 T30 P31 R32 H33 Y35 Q37 I39 G43 S44 E45 V46 V53 E54 K62 Y63 N66 K67 Q97 H99 R101

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:4u27, PDBe:4u27, PDBj:4u27
PDBsum	4u27
PubMed	24957822
UniProt	P0C018\|RL18_ECOLI Large ribosomal subunit protein uL18 (Gene Name=rplR)