Structure of PDB 7ane Chain BL

Receptor sequence

>7aneBL (length=309) Species: 5664 (Leishmania major)

VRSPDHGYSQHILQKDIWSPFQVGANMMSYTPLYYDWKGFSSRDYFGHRS
GTNPGSKVLLGHYRRDEVRSWGYRIMVNHKPQKRIPKWLACVVHIPRKKT
FLGFFLYANGAYVAELLTYKQLPRIIYNKAFQGCLPTIGQTVSLTEVTYG
KEIHSVEMYPGHGGVICRASGTAAVVLRGSEPNLVPLLLPSKEVRLFDNM
CHAVFGRRAGVMYNKQRNFSKRSVEENMPHRPKVHSKTKRVSSHPAGGGN
GGSPNLLTPLDWRIHPRNCVKTKYWLSGYILRGRQYNRNQTVADLKSKTY
SWANRDPVY

3D structure

• PDB: 7ane Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis.
• Chain: BL
• Resolution: 3.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	BL	L83 K108 R113 H118 R119 K127 L129 Y133 R134 R135 D136 R139 W141 K168 V235 I236 C237 R238 A239 S240 G241 T242 L259 P260 S261 E263 R265 V281 Y283 N284 K285 N288 R292 E295 M298 H300 R301 P302 K303 V304 H305 S306 K307 T308 K309 R310 S312 G318 G319 N320 G321 P324 N325 L327 P329 D331 R333 H335 R337 N338 C339 K341 T342 K343 S347 R354 Q355 R358 N359	L13 K38 R43 H48 R49 K57 L59 Y63 R64 R65 D66 R69 W71 K98 V165 I166 C167 R168 A169 S170 G171 T172 L189 P190 S191 E193 R195 V211 Y213 N214 K215 N218 R222 E225 M228 H230 R231 P232 K233 V234 H235 S236 K237 T238 K239 R240 S242 G248 G249 N250 G251 P254 N255 L257 P259 D261 R263 H265 R267 N268 C269 K271 T272 K273 S277 R284 Q285 R288 N289

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ane, PDBe:7ane, PDBj:7ane
• PDBsum: 7ane
• PubMed: 33168716
• UniProt: Q4QIE1