Structure of PDB 4u26 Chain BL

Receptor sequence

>4u26BL (length=143) Species: 83333 (Escherichia coli K-12)

RLNTLSPAEGSKKAGKRLGRGIGSGLGKTGGRGHKGQKSRSGGGVRRGFE
GGQMPLYRRLPKFGFTSRKAAITAEIRLSDLAKVEGGVVDLNTLKAANII
GIQIEFAKVILAGEVTTPVTVRGLRVTKGARAAIEAAGGKIEE

3D structure

• PDB: 4u26 Synergy of streptogramin antibiotics occurs independently of their effects on translation.
• Chain: BL
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	BL	L3 N4 L6 S7 P8 E10 G11 S12 K13 K14 G16 K17 R18 L19 G20 R21 G22 G24 S25 G28 K29 T30 G32 R33 G34 H35 K36 G37 Q38 K39 S40 R41 S42 G43 V46 R47 R48 F50 E51 G53 Q54 M55 Y58 R59 R60 L61 P62 K63 F64 G65 F66 S68 R69 K70 E76 R78 N99 Q104 K109 I111 L112 R126 T128 G130	L2 N3 L5 S6 P7 E9 G10 S11 K12 K13 G15 K16 R17 L18 G19 R20 G21 G23 S24 G27 K28 T29 G31 R32 G33 H34 K35 G36 Q37 K38 S39 R40 S41 G42 V45 R46 R47 F49 E50 G52 Q53 M54 Y57 R58 R59 L60 P61 K62 F63 G64 F65 S67 R68 K69 E75 R77 N98 Q103 K108 I110 L111 R125 T127 G129

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4u26, PDBe:4u26, PDBj:4u26
• PDBsum: 4u26
• PubMed: 24957822
• UniProt: P02413|RL15_ECOLI Large ribosomal subunit protein uL15 (Gene Name=rplO)