Structure of PDB 8oeq Chain BK

Receptor sequence

>8oeqBK (length=176) Species: 5476 (Candida albicans) [Search protein sequence]

VRYAATPANPAKSASARGSYLRVSFKNTRETAQAINGWKLEKAQKYLDQV
LDHQRAIPFRRYNSSIGRTGQGKEFGVTKARWPAKSVNFVKDLLRNAQAN
AEAKGLDSSKLVISHIQVNHAPKQRRRTYRAHGRINAYQSTPSHIELTLT
EEDEKQIRLNSRQRGRLASQKRLTAA

3D structure

PDB

8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement

Chain

Resolution

3.3 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	BK	V2 R3 Y4 S16 A17 R18 Y21 R23 S25 F26 K27 R30 Q34 K43 Q50 R56 R62 Y63 S65 S66 I67 G68 R69 G71 Q72 K74 E75 T79 K80 R82 W83 P84 A85 K86 R96 N97 A100 N101 Q118 V119 N120 H121 R127 T129 Y130 R131 A132 H133 G134 N137 A138 Y139 Q140 S141 T142 Q165 R167 N169 S170 R171 G174 R175 S178 R181 L182	V1 R2 Y3 S15 A16 R17 Y20 R22 S24 F25 K26 R29 Q33 K42 Q49 R55 R61 Y62 S64 S65 I66 G67 R68 G70 Q71 K73 E74 T78 K79 R81 W82 P83 A84 K85 R95 N96 A99 N100 Q117 V118 N119 H120 R126 T128 Y129 R130 A131 H132 G133 N136 A137 Y138 Q139 S140 T141 Q156 R158 N160 S161 R162 G165 R166 S169 R172 L173
BS02	rna	BK	A5 R61 R62 N120 H121 P123 H145	A4 R60 R61 N119 H120 P122 H144
BS03	MG	BK	S66 I67 G68	S65 I66 G67

External links

PDB	RCSB:8oeq, PDBe:8oeq, PDBj:8oeq
PDBsum	8oeq
PubMed
UniProt	A0A8H6BUG0

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