Structure of PDB 7o7z Chain BI

Receptor sequence

>7o7zBI (length=213) Species: 9986 (Oryctolagus cuniculus)

GRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLCGH
MVSDEYEQLSSEALEAARICANKYMVKSCGKDGFHIRVRLHPFHVIRINK
MLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNKEHVVEA
LRRAKFKFPGRQKIHISKKWGFTKFNADEFEDMVAEKRLIPDGCGVKYIP
NRGPLDKWRALHS

3D structure

• PDB: 7o7z Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
• Chain: BI
• Resolution: 2.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	BI	R110 L111	R109 L110
BS02	rna	BI	R3 R4 A6 R7 C8 K13 N14 K15 P16 Y17 F22 R24 K30 D35 K39 K40 S61 E63 A64 A67 K74 R90 H92 F94 R98 N100 C105 G107 D109 R110 Q112 G114 M115 R116 F119 G120 Q133 F157 K158 P160 D193 G194 K198	R2 R3 A5 R6 C7 K12 N13 K14 P15 Y16 F21 R23 K29 D34 K38 K39 S60 E62 A63 A66 K73 R89 H91 F93 R97 N99 C104 G106 D108 R109 Q111 G113 M114 R115 F118 G119 Q132 F156 K157 P159 D192 G193 K197
BS03	rna	BI	Y11 E56 Y57 I131 Y199 N202 R203 G204 P205 L206 W209	Y10 E55 Y56 I130 Y198 N201 R202 G203 P204 L205 W208

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0006412 translation
• GO:0006417 regulation of translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7o7z, PDBe:7o7z, PDBj:7o7z
• PDBsum: 7o7z
• PubMed: 34029205
• UniProt: B7NZQ2|RL10_RABIT Large ribosomal subunit protein uL16 (Gene Name=RPL10)