Structure of PDB 6tb3 Chain BI

Receptor sequence

>6tb3BI (length=294) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

QKDAKSSAYSSRFQTPFRRRREGKTDYYQRKRLVTQHKAKYNTPKYRLVV
RFTNKDIICQIISSTITGDVVLAAAYSHELPRYGITHGLTNWAAAYATGL
LIARRTLQKLGLDETYKGVEEVEGEYELTEAVEDGPRPFKVFLDIGLQRT
TTGARVFGALKGASDGGLYVPHSENRFPGWDFETEEIDPELLRSYIFGGH
VSQYMEELADDDEERFSELFKGYLADDIDADSLEDIYTSAHEAIRADPAF
KPTEKKFTKEQYAAESKKYRQTKLSKEERAARVAAKIAALAGQQ

3D structure

PDB

6tb3 The Ccr4-Not complex monitors the translating ribosome for codon optimality.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	BI	K8 Y12 R15 F16 Q17 P19 R23 T28 D29 R35 L36 K43 Y44 K48 L113 P139 R140 P141 F142 F145 I148 L150 R152 H175 S176 R179	K5 Y9 R12 F13 Q14 P16 R20 T25 D26 R32 L33 K40 Y41 K45 L110 P136 R137 P138 F139 F142 I145 L147 R149 H172 S173 R176
BS02	rna	BI	D6 S13 S14 F16 T18 F20 R21 R22 R24 K27 T28 Y30 R33 R50 R54 T56 N57 K58 I61 Q63 I65 I69 G71 D72 V74 Y79 H90 G91 N94 W95 Q151 R152 T155 R158 Y198 H203 V204 Y207 E210 R218 E221 K224 T256 K258 F260 K262 Q264 Y265 A266 E268 S269 K270 Y272 Q274 T275 K276 L277 K279 R282 R285 V286 K289	D3 S10 S11 F13 T15 F17 R18 R19 R21 K24 T25 Y27 R30 R47 R51 T53 N54 K55 I58 Q60 I62 I66 G68 D69 V71 Y76 H87 G88 N91 W92 Q148 R149 T152 R155 Y195 H200 V201 Y204 E207 R215 E218 K221 T253 K255 F257 K259 Q261 Y262 A263 E265 S266 K267 Y269 Q271 T272 K273 L274 K276 R279 R282 V283 K286

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6tb3, PDBe:6tb3, PDBj:6tb3
PDBsum	6tb3
PubMed	32299921
UniProt	P26321\|RL5_YEAST Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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