Structure of PDB 4v8z Chain BG

Receptor sequence

>4v8zBG (length=231) Species: 4932 (Saccharomyces cerevisiae)

NPLTHSTPKNFGIGQAVQPKRNLSRYVKWPEYVRVQRQKKILSIRLKVPP
TIAQFQYTLDRNTAAETFKLFNKYRPETAAEKKERLTKEAAAVAEGKSKQ
DASPKPYAVKYGLNHVVALIENKKAKLVLIANDVDPIELVVFLPALCKKM
GVPYAIVKGKARLGTLVNQKTSAVAALTEVRAEDEAALAKLVSTIDANFA
DKYDEVKKHWGGGILGNKAQAKMDKRAKNSD

3D structure

• PDB: 4v8z Molecular architecture of a eukaryotic translational initiation complex.
• Chain: BG
• Resolution: 6.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	BG	H28 S29 T30 P31 K32 N33 F34 I36 G37 Q38 V40 P42 K43 L46 R48 Y49 K51 P53 E54 Y55 R57 R60 L65 R68 L69 K105 K106 R108 D124 P129 K133 G135 L136 N137 H138 N145 K147 V157 D158 P159 L162 K183 A184 K193 T194 S195 A196 L238 G239 N240 K241 A242 A244 K248	H5 S6 T7 P8 K9 N10 F11 I13 G14 Q15 V17 P19 K20 L23 R25 Y26 K28 P30 E31 Y32 R34 R37 L42 R45 L46 K82 K83 R85 D101 P106 K110 G112 L113 N114 H115 N122 K124 V134 D135 P136 L139 K160 A161 K170 T171 S172 A173 L215 G216 N217 K218 A219 A221 K225
BS02	rna	BG	Y55 V56 Q59 R60 K63 K181 G182 R185	Y32 V33 Q36 R37 K40 K158 G159 R162

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000470 maturation of LSU-rRNA
• GO:0002181 cytoplasmic translation
• GO:0006364 rRNA processing
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v8z, PDBe:4v8z, PDBj:4v8z
• PDBsum: 4v8z
• PubMed: 24200810
• UniProt: P17076|RL8A_YEAST Large ribosomal subunit protein eL8A (Gene Name=RPL8A)