Structure of PDB 4v6v Chain BG

Receptor sequence

>4v6vBG (length=178) Species: 562 (Escherichia coli)

AKLHDYYKDEVVKKLMTEFNYNSVMQVPRVEKITLNMGVGEAIADKKLLD
NAAADLAAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFE
RLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRG
LDITITTTAKSDEEGRALLAAFDFPFRK

3D structure

• PDB: 4v6v Mechanism of tetracycline resistance by ribosomal protection protein Tet(O).
• Chain: BG
• Resolution: 9.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	BG	S72 G75 F76 K77 I78 R79	S72 G75 F76 K77 I78 R79
BS02	rna	BG	K32 T34 N36 M37 G38 V39 G40 E41 T67 K68 A69 R70 K71 V73 A74 I84 K87 K119 S120 R124 N126 S128 M129 G130 R132 G150 L151 D152 I153 T154 T156 R177	K32 T34 N36 M37 G38 V39 G40 E41 T67 K68 A69 R70 K71 V73 A74 I84 K87 K119 S120 R124 N126 S128 M129 G130 R132 G150 L151 D152 I153 T154 T156 R177
BS03	rna	BG	S23 M25 Q26 R29 Q62 K63 L65 I66 K87 V88 T89 R91	S23 M25 Q26 R29 Q62 K63 L65 I66 K87 V88 T89 R91

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v6v, PDBe:4v6v, PDBj:4v6v
• PDBsum: 4v6v
• PubMed: 23403578
• UniProt: P62399|RL5_ECOLI Large ribosomal subunit protein uL5 (Gene Name=rplE)