Structure of PDB 5t0c Chain BF

Receptor sequence
>5t0cBF (length=366) Species: 9606 (Homo sapiens) [Search protein sequence]
THELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDSQRKGKCAV
IKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVK
AMEVDERPTEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGV
LMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKLVRDAFA
LAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPN
TQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKM
NVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEG
ILEVQAKKKANLQYYA
3D structure
PDB5t0c Structural basis for dynamic regulation of the human 26S proteasome.
ChainBF
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP BF D318 A341 R344 R347 D245 A268 R271 R274
BS02 ATP BF I188 P229 G230 T231 G232 K233 T234 L235 N333 I365 G393 A394 K397 I115 P156 G157 T158 G159 K160 T161 L162 N260 I292 G320 A321 K324
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
GO:0042802 identical protein binding
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043921 modulation by host of viral transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0000932 P-body
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex
GO:0034774 secretory granule lumen
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5t0c, PDBe:5t0c, PDBj:5t0c
PDBsum5t0c
PubMed27791164
UniProtP17980|PRS6A_HUMAN 26S proteasome regulatory subunit 6A (Gene Name=PSMC3)

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