Structure of PDB 8cq7 Chain BE

Receptor sequence

>8cq7BE (length=208) Species: 5476 (Candida albicans) [Search protein sequence]

ARRPARCYRYCKNKPYPKSRYNRAVPDAKIRIYDLGRKKATVDEFPLCIH
LVSNELEQLSSEALEAARICANKYITKVSGRDSFHLRVRVHPFHVLRINK
MQGMRGAWGKPHGLAARVSIGQIIMSARTKDSNKDVVIEGLRRARYKFPG
QQKIIISKKWGFTPLNRDEYIAKKTNGEVIDDGAYVKFLSRKGNLEANLQ
QFPNYQYS

3D structure

PDB

8cq7 Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement

Chain

Resolution

3.2 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	BE	R3 R4 A6 R7 C8 K13 N14 K15 Y17 Y22 R24 Y34 D35 K39 S61 E63 A64 A67 K74 R90 H92 F94 R98 N100 G114 M115 R116 W119 G120 Q133 R154 Y157 K158 P160 D193 G194 A195 Y196 K198	R2 R3 A5 R6 C7 K12 N13 K14 Y16 Y21 R23 Y33 D34 K38 S60 E62 A63 A66 K73 R89 H91 F93 R97 N99 G103 M104 R105 W108 G109 Q122 R143 Y146 K147 P149 D182 G183 A184 Y185 K187
BS02	rna	BE	Y11 E56 L57 I131 R202 K203 G204 L206 N209	Y10 E55 L56 I120 R191 K192 G193 L195 N198
BS03	MG	BE	R156 F159 G161 Q163	R145 F148 G150 Q152

External links

PDB	RCSB:8cq7, PDBe:8cq7, PDBj:8cq7
PDBsum	8cq7
PubMed
UniProt	Q5AIB8\|RL10_CANAL Large ribosomal subunit protein uL16 (Gene Name=RPL10)

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