Structure of PDB 6lqu Chain BE

Receptor sequence

>6lquBE (length=865) Species: 559292 (Saccharomyces cerevisiae S288C)

KNSKIFSPFRIIGNVSNGVPFATGTLGSTFYIVTCVGKTFQIYDANTLHL
LFVSEKETPSSIVALSAHFHYVYAAYENKVGIYKRGIEEHLLELETDANV
EHLCIFGDYLCASTDDNSIFIYKKSDPQDKYPSEFYTKLTVTEIQGGEIV
SLQHLATYLNKLTVVTKSNVLLFNVRTGKLVFTSNEFPDQITTAEPAPVL
DIIALGTVTGEVIMFNMRKGKRIRTIKIPQSRISSLSFRTDGSSHLSVGT
SSGDLIFYDLDRRSRIHVLKNIHRESYGGVTQATFLNGQPIIVTSGGDNS
LKEYVFDPSLSQGSGDVVVQPPRYLRSRGGHSQPPSYIAFADSQSHFMLS
ASKDRSLWSFSLRKDAQSQEMSQRLHKKQDGGRVGGSTIKSKFPEIVALA
IENARIGEWENIITAHKDEKFARTWDMRNKRVGRWTFDTTDDGFVKSVAM
SQCGNFGFIGSSNGSITIYNMQSGILRKKYKLHKRAVTGISLDGMNRKMV
SCGLDGIVGFYDFNKSTLLGKLKLDAPITAMVYHRSSDLFALALDDLSIV
VIDAVTQRVVRQLWGHSNRITAFDFSPEGRWIVSASLDSTIRTWDLPTGG
CIDGIIVDNVATNVKFSPNGDLLATTHVTGNGICIWTNRAQFKTVSTRTI
DELNDIDFNTYTSLEQIDKELLTLSIGPRSKMNTLLHLDVIRKRSKPKEA
PKKSEKLPFFLQLSGEKSVREGIAHETPEEFKVTGRLGFESHFTKQLREG
SQSKDYSSLLATLINFSPAAVDLEIRSLNSFEPFDEIVWFIDALTQGLKS
NKNFELYETFMSLLFKAHGDVIHANNKNQDIASALQNWEDVHKKEDRLDD
LVKFCMGVAAFVTTA

3D structure

• PDB: 6lqu Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states.
• Chain: BE
• Resolution: 3.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	BE	S390 R392 N447 R449	S372 R374 N429 R431
BS02	rna	BE	L44 G45 T47 L68 L69 F70 F87 H88 R103 R341 R344 R346 H364 R381 K382 D383 Q385 R401 G403 G404 S405 T406 I407	L26 G27 T29 L50 L51 F52 F69 H70 R85 R323 R326 R328 H346 R363 K364 D365 Q367 R383 G385 G386 S387 T388 I389

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0005515 protein binding

Biological Process

• GO:0006364 rRNA processing
• GO:0030490 maturation of SSU-rRNA
• GO:0042254 ribosome biogenesis

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0030686 90S preribosome
• GO:0032040 small-subunit processome
• GO:0034388 Pwp2p-containing subcomplex of 90S preribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6lqu, PDBe:6lqu, PDBj:6lqu
• PDBsum: 6lqu
• PubMed: 32943522
• UniProt: Q06078|UTP21_YEAST U3 small nucleolar RNA-associated protein 21 (Gene Name=UTP21)