Structure of PDB 5t0c Chain BE

Receptor sequence
>5t0cBE (length=353) Species: 9606 (Homo sapiens) [Search protein sequence]
TKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQ
LDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIG
GLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARA
VASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEID
AIGGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLD
PALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSD
GFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDY
KPV
3D structure
PDB5t0c Structural basis for dynamic regulation of the human 26S proteasome.
ChainBE
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP BE D265 R291 R294 D229 R255 R258
BS02 ATP BE I135 P175 T178 G179 K180 T181 L182 I312 A341 I99 P139 T142 G143 K144 T145 L146 I276 A305
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0030674 protein-macromolecule adaptor activity
GO:0036402 proteasome-activating activity
GO:0042802 identical protein binding
Biological Process
GO:0036503 ERAD pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0090261 positive regulation of inclusion body assembly
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0016234 inclusion body
GO:0022624 proteasome accessory complex
GO:0031597 cytosolic proteasome complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5t0c, PDBe:5t0c, PDBj:5t0c
PDBsum5t0c
PubMed27791164
UniProtP62333|PRS10_HUMAN 26S proteasome regulatory subunit 10B (Gene Name=PSMC6)

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