Structure of PDB 8oeq Chain BC

Receptor sequence

>8oeqBC (length=233) Species: 5476 (Candida albicans) [Search protein sequence]

NPLFESTPKNFGIGQSIQPKRNLSRFVKWPEYVRLQRQKKILSLRLKVPP
SIAQFSQTLDKNTAAQAFKLLNKYRPETSAEKKERLTKEAAAIAEGKTAK
DVSPKPVVVKYGLNHVVSLIENKKAKLVLIANDVDPIELVVFLPALCKKM
GVPYAIVKGKARLGTLVHKKTSAVAALTEVNSADEAELSKLISTINANYI
EKYEENRKHWGGGIMGSKANDKIAKKAKAAAAA

3D structure

PDB

8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement

Chain

Resolution

3.3 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	BC	E29 S30 T31 K33 N34 F35 I37 G38 Q39 Q42 P43 S48 R49 F50 K52 P54 E55 Y56 R58 R61 R69 L70 K71 E101 K106 K107 R109 K124 S127 P128 K129 P130 K134 Y135 G136 L137 N138 H139 S142 L143 N146 K148 D159 L163 K184 A185 K193 K194 T195 S196 A197 M239 G240 S241 K242 A243 D245	E5 S6 T7 K9 N10 F11 I13 G14 Q15 Q18 P19 S24 R25 F26 K28 P30 E31 Y32 R34 R37 R45 L46 K47 E77 K82 K83 R85 K100 S103 P104 K105 P106 K110 Y111 G112 L113 N114 H115 S118 L119 N122 K124 D135 L139 K160 A161 K169 K170 T171 S172 A173 M215 G216 S217 K218 A219 D221
BS02	rna	BC	Y56 V57 Q60 R61 K64 K85 R186	Y32 V33 Q36 R37 K40 K61 R162

External links

PDB	RCSB:8oeq, PDBe:8oeq, PDBj:8oeq
PDBsum	8oeq
PubMed
UniProt	A0A8H6C337

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