Structure of PDB 4v73 Chain BC

Receptor sequence

>4v73BC (length=271) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

AVVKCKPTSPGRRHVVKVVNPELHKGKPFAPLLEKNSKSGGRNNNGRITT
RHIGGGHKQAYRIVDFKRNKDGIPAVVERLEYDPNRSANIALVLYKDGER
RYILAPKGLKAGDQIQSGVDAAIKPGNTLPMRNIPVGSTVHNVEMKPGKG
GQLARSAGTYVQIVARDGAYVTLRLRSGEMRKVEADCRATLGEVGNAEHM
LRVLGKAGAARWRGVRPTVRGTAMNPVDHPHGGGEGRNFGKHPVTPWGVQ
TKGKKTRSNKRTDKFIVRRRS

3D structure

PDB

4v73 Energy barriers and driving forces in tRNA translocation through the ribosome.

Chain

Resolution

15.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	BC	V136 G137 Q162 V164 R174 M180 L201 V267 R268	V136 G137 Q162 V164 R174 M180 L201 V267 R268
BS02	rna	BC	K6 P7 T8 S9 R13 H14 K25 G26 K27 K35 N36 K38 R42 N43 R47 I48 T49 T50 R51 H52 G55 G56 K58 Q59 A60 Y61 R62 K70 Y82 P84 R86 S87 K96 D97 G98 E99 R100 M145 K146 P147 K149 G151 L153 A154 R155 S156 A157 G158 T159 Y170 R176 S177 E179 R181 M200 V203 K206 A207 G208 R211 W212 R213 R216 R220 G221 T222 A223 M224 H229 P230 H231 E235 G236 R237 N238 F239 G240 K241 H242 P246 W247 G248 Q250 K252 G253 K254 K255 T256 R257 K260 R261 T262 R269 R270	K6 P7 T8 S9 R13 H14 K25 G26 K27 K35 N36 K38 R42 N43 R47 I48 T49 T50 R51 H52 G55 G56 K58 Q59 A60 Y61 R62 K70 Y82 P84 R86 S87 K96 D97 G98 E99 R100 M145 K146 P147 K149 G151 L153 A154 R155 S156 A157 G158 T159 Y170 R176 S177 E179 R181 M200 V203 K206 A207 G208 R211 W212 R213 R216 R220 G221 T222 A223 M224 H229 P230 H231 E235 G236 R237 N238 F239 G240 K241 H242 P246 W247 G248 Q250 K252 G253 K254 K255 T256 R257 K260 R261 T262 R269 R270

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016740	transferase activity
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0032297	negative regulation of DNA-templated DNA replication initiation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0022625	cytosolic large ribosomal subunit
GO:1990082	DnaA-L2 complex
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4v73, PDBe:4v73, PDBj:4v73
PDBsum	4v73
PubMed	24186064
UniProt	P60422\|RL2_ECOLI Large ribosomal subunit protein uL2 (Gene Name=rplB)

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