Structure of PDB 8vzv Chain BBB

Receptor sequence

>8vzvBBB (length=344) Species: 9606 (Homo sapiens) [Search protein sequence]

GGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQIL
WELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTA
LDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYYRDNFKGEENEL
LLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRI
QAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQG
ALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAG
SGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFL

3D structure

PDB

8vzv Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.

Chain

BBB

Resolution

2.29 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	A1AER	BBB	Y42 Y45	Y5 Y8
BS02	HEM	BBB	F72 H76 Y79 L132 S151 G152 F153 F158 R159 Y175 W324 H328 M331 V332 Y350	F35 H39 Y42 L95 S114 G115 F116 F121 R122 Y138 W283 H287 M290 V291 Y305
BS03	ZIQ	BBB	R103 E105 W208 R211 T212 P213 F304 P307	R66 E68 W167 R170 T171 P172 F263 P266
BS04	A1AER	BBB	F72 R144 A150 G341	F35 R107 A113 G300

External links

PDB	RCSB:8vzv, PDBe:8vzv, PDBj:8vzv
PDBsum	8vzv
PubMed	39106326
UniProt	P48775\|T23O_HUMAN Tryptophan 2,3-dioxygenase (Gene Name=TDO2)

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