Structure of PDB 8br6 Chain BBB

Receptor sequence
>8br6BBB (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
FHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKK
LAALKQQFDQEIKVMAKCQHENLVELLGFSSDLCLVYVYMPNGSLLDRLS
CLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTA
KISDFGLARQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEII
TGLPAVDEHREPQLLLDIAAAIEDEEKTIEDYIDKKMNDADSTSVEAMYS
VASQCLHEKKNKRPDIKKVQQLLQEMTA
3D structure
PDB8br6 Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839 .
ChainBBB
Resolution2.167 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R6I BBB M192 V200 A211 V246 Y262 Y264 M265 P266 N267 G268 R273 L318 M28 V36 A47 V74 Y87 Y89 M90 P91 N92 G93 R98 L143
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:8br6, PDBe:8br6, PDBj:8br6
PDBsum8br6
PubMed38228402
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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