Structure of PDB 8atl Chain BBB

Receptor sequence
>8atlBBB (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
FHSFSFYELKNVTNNFDERPISGNKMGEGVVYKGYVNNTTVAVKKLLKQQ
FDQEIKVMAKCQHENLVELLGFSSDGLCLVYVYMPNGSLLDRLSCLDGTP
PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFG
LARTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVD
EHREPQLLLDIAAAIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLH
EKKNKRPDIKKVQQLLQEMTA
3D structure
PDB8atl Discovery of IRAK4 Inhibitors BAY1834845 and BAY1830839
ChainBBB
Resolution2.464 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 O6X BBB M192 V200 A211 K213 V246 Y262 Y264 M265 P266 N267 G268 L318 D329 M26 V31 A42 K44 V67 Y81 Y83 M84 P85 N86 G87 L137 D148
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8atl, PDBe:8atl, PDBj:8atl
PDBsum8atl
PubMed38228402
UniProtQ9NWZ3|IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 (Gene Name=IRAK4)

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