Structure of PDB 8am8 Chain BBB

Receptor sequence

>8am8BBB (length=535) Species: 596154 (Alicycliphilus denitrificans K601) [Search protein sequence]

SFSAEYDIVVVGSGCAGLTSALFSRWHGNSVVVLEKAAALGGTTFKSAFA
YWVPNNVPMRAAGIADPKPDFLKYVARVTRPQFYDPEHPTLGLTQWEYDM
CEAIYDSASPAAELLAQKGALPYRHVPFATDYFSELPEDKAKSGRVLTPK
DGSPSMANGGQVAIRTLSTAARRDGIAFKTGHRVQRVILNSKGEAIGIEA
LKDDNSVVRIRARKAVIFGSGGFTHDPELRSNFLNVPVYGGCAAFTNEGD
LVRITSSLGVQLRNMNHAWLCPVTFEKAIGRDGSMSGMFSVAGDSMIFVD
KRGKRVVNEKLNYNELCQKLFEWDGAKVEYPNLVLISIWDQRSQDHSASN
DYGSAIVPPGADDRHVIKSDTLDGLSQQISLRLKKYAGQIGHMELSSDFN
ANLRESILRFNGFASTGKDEDFHRGERASDVLFNGSTKKEPDQKNPTMWP
ISSVGPYYAALVGGGTLDTKGGPKTNTHGQILDIHDKPIRGLYGVGNCVA
SASSGAYWAGGATLGPMIAFAYRAANAAHGEPKRT

3D structure

PDB

8am8 Rational design of cyclohexanone dehydrogenase for enhanced alpha, beta-desaturation and substrate specificity of cyclic ketones

Chain

BBB

Resolution

1.85 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	BBB	V74 G75 G77 A79 E98 K99 G105 T106 T107 S110 A111 A113 V247 S283 G284 C305 T309 N310 D313 S349 F352 L530 N560 G574 T576 L577 M580	V11 G12 G14 A16 E35 K36 G42 T43 T44 S47 A48 A50 V184 S220 G221 C242 T246 N247 D250 S286 F289 L467 N497 G511 T513 L514 M517
BS02	A2Q	BBB	F352 Y376 Y570 G573	F289 Y313 Y507 G510

External links

PDB	RCSB:8am8, PDBe:8am8, PDBj:8am8
PDBsum	8am8
PubMed	38550701
UniProt	F4G7N3

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