Structure of PDB 7zw3 Chain BBB

Receptor sequence
>7zw3BBB (length=495) Species: 9606 (Homo sapiens) [Search protein sequence]
SNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKV
KYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRG
PFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKEL
LDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIIST
TNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLN
HEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYY
KEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARK
LARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTY
FPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREIL
HAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLI
3D structure
PDB7zw3 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases.
ChainBBB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.4.3.21: primary-amine oxidase.
1.4.3.4: monoamine oxidase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008131 primary methylamine oxidase activity
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0050660 flavin adenine dinucleotide binding
GO:0052595 aliphatic amine oxidase activity
GO:0097621 monoamine oxidase activity
Biological Process
GO:0009410 response to xenobiotic stimulus
GO:0009636 response to toxic substance
GO:0010044 response to aluminum ion
GO:0010269 response to selenium ion
GO:0014063 negative regulation of serotonin secretion
GO:0019607 phenylethylamine catabolic process
GO:0021762 substantia nigra development
GO:0032496 response to lipopolysaccharide
GO:0042420 dopamine catabolic process
GO:0045471 response to ethanol
GO:0045964 positive regulation of dopamine metabolic process
GO:0048545 response to steroid hormone
GO:0050665 hydrogen peroxide biosynthetic process
GO:0051412 response to corticosterone
Cellular Component
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005741 mitochondrial outer membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zw3, PDBe:7zw3, PDBj:7zw3
PDBsum7zw3
PubMed37250172
UniProtP27338|AOFB_HUMAN Amine oxidase [flavin-containing] B (Gene Name=MAOB)

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