Structure of PDB 7z43 Chain BBB

Receptor sequence
>7z43BBB (length=750) Species: 11520 (Influenza B virus) [Search protein sequence]
GMNINPYFLFIDVPIQAAISTTFPYTGVPPYSHGTGTGYTIDTVIRTHEY
SNKGKQYISDVTGCTMVDPTNGPLPEDNEPSAYAQLDCVLEALDRMDEEH
PGLFQAASQNAMETLMVTTVDKLTQGRQTFDWTVCRNQPAATALNTTITS
FRLNDLNGADKGGLIPFCQDIIDSLDRPEMTFFSVKNIKKKLPAKNRKGF
LIKRIPMKVKDKITKVEYIKRALSLNTMTKDAERGKLKRRAIATAGIQIR
GFVLVVENLAKNICENLEQSGLPVGGNEKKAKLSNAVAKMLSNCPPGGIS
MTVTGDNTKWNECLNPRIFLAMTERITRDSPIWFRDFCSIAPVLFSNKIA
RLGKGFMITSKTKRLKAQIPCPDLFSIPLERYNEETRAKLKKLKPFFNEE
GTASLSPGMMMGMFNMLSTVLGVAALGIKNIGNKEYLWDGLQSSDDFALF
VNAKDEETCMEGINDFYRTCKLLGINMSKKKSYCNETGMFEFTSMFYRDG
FVSNFAMELPSFGVAGVNESADMAIGMTIIKNNMINNGMGPATAQTAIQL
FIADYRYTYKCHRGDSKVEGKRMKIIKELWENTKGRDGLLVADGGPNIYN
LRNLHIPEIVLKYNLMDPEYKGRLLHPQNPFVGHLSIEGIKEADITPAHG
PVKKMDYDAVSGTHSWRTKRNRSILNTDQRNMILEEQCYAKCCNLFEACF
NSASYRKPVGQHSMLEAMAHRLRMDARLDYESGRMSKDDFEKAMAHLGEI
3D structure
PDB7z43 Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
ChainBBB
Resolution3.123 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna BBB R126 Q127 M227 K229 D230 I241 T243 R249 M410 M412 N414 N670 R671 S672 N675 R127 Q128 M228 K230 D231 I242 T244 R250 M411 M413 N415 N671 R672 S673 N676
BS02 rna BBB H32 G33 T34 Y38 M356 K365 E384 H33 G34 T35 Y39 M357 K366 E385
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z43, PDBe:7z43, PDBj:7z43
PDBsum7z43
PubMed35605026
UniProtQ5V8Y6

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