Structure of PDB 7yzh Chain BBB

Receptor sequence
>7yzhBBB (length=276) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
EWSYTNILTGPETWHEHYKNMCSGYYQSPIDLKTDISTLDLKLKTVIIYR
NTSSTETTTIQNNGHSAEVKFPRNTWFISFDGILDYKYEIIQMHFHWGNT
DDRGSEHTIDGFRFPLEGHIVSFRRQMYSSPSEAIGRPGGLAVLGIMHQI
VESIKYEQTAFKAYNNFSGVLNSQFVPPNNSTIDDINLALLLSLLNPSRY
FRYLGSLTTPPCTENVLWTVFIDPVLITREQINLFRNLPYGSNEKQTRMG
DNFRPIQLLNPIDTLASRTLYRATAR
3D structure
PDB7yzh Development of Praziquantel sulphonamide derivatives as antischistosomal drugs.
ChainBBB
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN BBB H117 H119 H142 H94 H96 H119
BS02 HFF BBB Q115 H117 H142 S155 L230 T231 T232 Q92 H94 H119 S132 L207 T208 T209
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:7yzh, PDBe:7yzh, PDBj:7yzh
PDBsum7yzh
PubMed35635137
UniProtA0A3Q0KSG2

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