Structure of PDB 7qnh Chain BBB

Receptor sequence
>7qnhBBB (length=383) Species: 511145 (Escherichia coli str. K-12 substr. MG1655) [Search protein sequence]
ANRMILNETAWFGRGAVGALTDEVKRRGYQKALIVTDKTLVQCGVVAKVT
DKMDAAGLAWAIYDGVVPNPTITVVKEGLGVFQNSGADYLIAIGGGSPQD
TCKAIGIISNNPEFADVRSLEGLSPTNKPSVPILAIPTTAGTAAEVTIGY
VITDEEKRRKFVCVDPHDIPQVAFIDADMMDGMPPALKAATGVDALTHAI
EGYITRGAWALTDALHIKAIEIIAGALRGSVAGDKDAGEEMALGQYVAGM
GFSNVGVGLVHGMAHPLGAFYNTPHGVANAILLPHVMRYNADFTGEKYRD
IARVMGVKVEGMGLEEARNAAVEAVFALNRDVGIPPHLRDVGVRKEDIPA
LAQAALDDVCTGGNPREATLEDIVELYHTAWTS
3D structure
PDB7qnh Crystal structures and kinetic studies of a laboratory evolved aldehyde reductase explain the dramatic shift of its new substrate specificity.
ChainBBB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.77: lactaldehyde reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI BBB D39 T41 L42 P70 N71 G97 G98 S99 D102 T140 T141 T144 T149 G151 K162 L189 H200 H277 D37 T39 L40 P68 N69 G95 G96 S97 D100 T138 T139 T142 T147 G149 K160 L187 H198 H275
BS02 FE BBB D196 H200 H263 H277 D194 H198 H261 H275
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004022 alcohol dehydrogenase (NAD+) activity
GO:0008198 ferrous iron binding
GO:0008912 lactaldehyde reductase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0052660 R-lactaldehyde reductase activity
GO:0052661 S-lactaldehyde reductase activity
Biological Process
GO:0006004 fucose metabolic process
GO:0019301 rhamnose catabolic process
GO:0019317 fucose catabolic process
GO:0042355 L-fucose catabolic process
GO:0042846 glycol catabolic process
GO:0051143 propanediol metabolic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:7qnh, PDBe:7qnh, PDBj:7qnh
PDBsum7qnh
PubMed37261425
UniProtP0A9S1|FUCO_ECOLI Lactaldehyde reductase (Gene Name=fucO)

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