Structure of PDB 7ojo Chain BBB

Receptor sequence
>7ojoBBB (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVC
NKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYI
GGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRV
TLGKSFLQFS
3D structure
PDB7ojo Tankyrase 2 in complex with an inhibitor (OM-153)
ChainBBB
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WQG BBB H1031 G1032 Y1060 S1068 Y1071 H80 G81 Y109 S117 Y120
BS02 VGZ BBB H1031 F1035 A1038 I1039 G1043 F1044 D1045 H1048 I1059 Y1060 H80 F84 A87 I88 G92 F93 D94 H97 I108 Y109
BS03 ZN BBB C1081 H1084 C1089 C1092 C130 H133 C138 C141
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7ojo, PDBe:7ojo, PDBj:7ojo
PDBsum7ojo
PubMed
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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