Structure of PDB 7o6x Chain BBB

Receptor sequence
>7o6xBBB (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]
GSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQK
VCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHA
YIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFC
RVTLGKSFLQ
3D structure
PDB7o6x Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II.
ChainBBB
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V4Q BBB H1031 S1033 F1035 A1038 I1039 G1043 F1044 D1045 H1048 Y1050 I1059 Y1060 Y1071 I1075 H82 S84 F86 A89 I90 G94 F95 D96 H99 Y101 I110 Y111 Y122 I126
BS02 ZN BBB C1081 H1084 C1089 C1092 C132 H135 C140 C143
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7o6x, PDBe:7o6x, PDBj:7o6x
PDBsum7o6x
PubMed34878777
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

[Back to BioLiP]