Structure of PDB 7o00 Chain BBB

Receptor sequence
>7o00BBB (length=180) Species: 9606 (Homo sapiens) [Search protein sequence]
DTRPRFLEQVKHECHFFNGTERVRFLDRYFYHQEEYVRFDSDVGEYRAVT
ELGRPDAEYWNSQKDLLEQKRAAVDTYCRHNYGVGESFTVQRRVYPEVTV
YPAKTNLLVCSVNGFYPGSIEVRWFRNGQEEKTGVVSTGLIQNGDWTFQT
LVMLETVPEVYTCQVEHPSLTSPLTVEWRA
3D structure
PDB7o00 Key interactions in the trimolecular complex consisting of the rheumatoid arthritis-associated DRB1*04:01 molecule, the major glycosylated collagen II peptide and the T-cell receptor.
ChainBBB
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide BBB H13 Y30 Y47 D57 Y60 W61 L67 Y78 H81 N82 V85 H12 Y29 Y46 D56 Y59 W60 L66 Y77 H80 N81 V84
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:7o00, PDBe:7o00, PDBj:7o00
PDBsum7o00
PubMed35027402
UniProtA0A1V1IGJ9

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