Structure of PDB 7nb2 Chain BBB

Receptor sequence
>7nb2BBB (length=352) Species: 9606 (Homo sapiens) [Search protein sequence]
QPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPD
TTATLGDEPRKVLLRLYGAEAMVLESVMFAILAERSLGPKLYGIFPQGRL
EQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEK
YLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHN
DCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYS
YEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEM
LLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKL
GV
3D structure
PDB7nb2 Identification of unprecedented ATP-competitive choline kinase inhibitors.
ChainBBB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.32: choline kinase.
2.7.1.82: ethanolamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U6E BBB I116 P194 F208 I209 S211 R213 I329 I35 P89 F103 I104 S106 R108 I224
BS02 MG BBB E309 E349 Y352 E204 E244 Y247
External links
PDB RCSB:7nb2, PDBe:7nb2, PDBj:7nb2
PDBsum7nb2
PubMed34416377
UniProtP35790|CHKA_HUMAN Choline kinase alpha (Gene Name=CHKA)

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