Structure of PDB 7mx6 Chain BBB

Receptor sequence
>7mx6BBB (length=306) Species: 5664 (Leishmania major) [Search protein sequence]
SMSLQVNLLNNTFANPFMNAAGVMCTTTEELVAMTESASGSLVSKSCTPA
LREGNPTPRYQALPLGSINSMGLPNNGFDFYLAYAAEQHDYGKKPLFLSM
SGLSMRENVEMCKRLAAVATEKGVILELNLSPQVAYDFDAMRQCLTAVSE
VYPHSFGVKMPPYFDFAHFDAAAEILNEFPKVQFITCINSIGNGLVIDAE
TESVVIKPKQGFGGLGGRYVLPTALANINAFYRRCPGKLIFGCGGVYTGE
DAFLHVLAGASMVQVGTALQEEGPSIFERLTSELLGVMAKKRYQTLDEFR
GKVRTL
3D structure
PDB7mx6 Leishmania major dihydroorotate dehydrogenase in complex with [4-(1H-pyrrol-1-yl)phenyl]methanol
ChainBBB
Resolution1.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.3.98.1: dihydroorotate oxidase (fumarate).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SNU BBB Y142 F170 H174 Y136 F164 H168
BS02 FMN BBB A19 A20 G21 K44 S45 Y59 N68 M70 N128 K165 I194 N195 G222 G223 C249 G250 G251 G272 T273 A20 A21 G22 K45 S46 Y60 N69 M71 N129 K159 I188 N189 G216 G217 C243 G244 G245 G266 T267
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004152 dihydroorotate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:1990663 dihydroorotate dehydrogenase (fumarate) activity
Biological Process
GO:0006106 fumarate metabolic process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0097014 ciliary plasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7mx6, PDBe:7mx6, PDBj:7mx6
PDBsum7mx6
PubMed
UniProtQ4QEW7

[Back to BioLiP]