Structure of PDB 6z4n Chain BBB

Receptor sequence
>6z4nBBB (length=318) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2) [Search protein sequence]
HMSKIYEDNSLTIGHTPLVRLNRIGNGRILAKVESRNPSFSVKCRIGANM
IWDAEKRGVLKPGVELVEPTSGNTGIALAYVAAARGYKLTLTMPETMSIE
RRKLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPQKYLLLQQFSNPAN
PEIHEKTTGPEIWEDTDGQVDVFISGVGTGGTLTGVTRYIKGTKGKTDLI
TVAVEPTDSPVIAQALAGEEIKPGPHKIQGIGAGFIPGNLDLKLIDKVVG
ITNEEAISTARRLMEEEGILAGISSGAAVAAALKLQEDESFTNKNIVVIL
PSSGERYLSTALFADLFT
3D structure
PDB6z4n Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O -Acetylserine Sulfhydrylase as a Colistin Adjuvant.
ChainBBB
Resolution1.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.47: cysteine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP BBB K41 N71 V175 G176 T177 G178 T180 G228 S272 P299 K43 N73 V177 G178 T179 G180 T182 G230 S274 P301
BS02 Q7B BBB K41 T68 G70 N71 T72 M119 Q142 F143 G228 A231 K43 T70 G72 N73 T74 M121 Q144 F145 G230 A233
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0019344 cysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6z4n, PDBe:6z4n, PDBj:6z4n
PDBsum6z4n
PubMed33513010
UniProtP0A1E3|CYSK_SALTY Cysteine synthase A (Gene Name=cysK)

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