Structure of PDB 6z1t Chain BBB

Receptor sequence
>6z1tBBB (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
SVEEYLVHALQGSVSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVL
LTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKV
RLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLV
KEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAA
LCDFGHAVCLDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGC
HPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVS
AAELGGKVNRALQQVGGLKSPWRGEYKEPRHPPP
3D structure
PDB6z1t FEP+ calculations predict a stereochemical SAR switch for first-in-class indoline NIK inhibitors for multiple myeloma
ChainBBB
Resolution2.31 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D515
Catalytic site (residue number reindexed from 1) D184
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q55 BBB L406 G407 R408 V414 A427 K429 L471 L472 G475 L522 C533 D534 L75 G76 R77 V83 A96 K98 L140 L141 G144 L191 C202 D203
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6z1t, PDBe:6z1t, PDBj:6z1t
PDBsum6z1t
PubMed
UniProtQ99558|M3K14_HUMAN Mitogen-activated protein kinase kinase kinase 14 (Gene Name=MAP3K14)

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