Structure of PDB 6y2j Chain BBB

Receptor sequence
>6y2jBBB (length=415) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
SQPSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHALEDEFV
TKWDLAVKIGGHLKDPVDSHMGRLDMRRMSYVQRMGKLLGGQLWESAGSP
EVDPDRFAVVVGTGLGGAERIVESYDLMNAGGPRKVSPLAVQMIMPNGAA
AVIGLQLGARAGVMTPVSACSSGSEAIAHAWRQIVMGDADVAVCGGVEGP
IEALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFGEAGALMLIETE
EHAKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGLS
PADIDHVNAHGTATPIGDAAEANAIRVAGCDQAAVYAPKSALGHSIGAVG
ALESVLTVLTLRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYRYAVNNS
FGFGGHNVALAFGRY
3D structure
PDB6y2j Exploring the SAR of the beta-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.
ChainBBB
Resolution2.886 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C171 H311 E322 K340 H345 F402 F404
Catalytic site (residue number reindexed from 1) C170 H310 E321 K339 H344 F401 F403
Enzyme Commision number 2.3.1.293: meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 O6W BBB E120 E199 G200 P201 P206 E241 I347 E119 E198 G199 P200 P205 E240 I346
Gene Ontology
Molecular Function
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0042802 identical protein binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0019367 fatty acid elongation, saturated fatty acid
GO:0030497 fatty acid elongation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6y2j, PDBe:6y2j, PDBj:6y2j
PDBsum6y2j
PubMed32196311
UniProtP9WQD9|KASA_MYCTU 3-oxoacyl-[acyl-carrier-protein] synthase 1 (Gene Name=kasA)

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