Structure of PDB 6tkr Chain BBB

Receptor sequence
>6tkrBBB (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
SGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKV
CNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAY
IGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCR
VTLGKSFLQFSMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLI
TYQIMRPE
3D structure
PDB6tkr Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.
ChainBBB
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NJK BBB H1031 S1033 F1035 A1038 I1039 D1045 H1048 Y1050 I1059 Y1060 Y1071 I1075 H81 S83 F85 A88 I89 D95 H98 Y100 I109 Y110 Y121 I125
BS02 ZN BBB C1081 H1084 C1089 C1092 C131 H134 C139 C142
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6tkr, PDBe:6tkr, PDBj:6tkr
PDBsum6tkr
PubMed32511917
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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