Structure of PDB 6t8w Chain BBB

Receptor sequence
>6t8wBBB (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
SLCGMVWEHTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCF
TVDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVA
LIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDI
KALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTP
RFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKVP
AHARDFHINLFQVLPWLKEKLQDEDLGFL
3D structure
PDB6t8w Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
ChainBBB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.47: alternative-complement-pathway C3/C5 convertase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN BBB D171 H223 D181 H252
BS02 MVW BBB P172D T190 C191 R192 S195 W215 G216 V217 V218 D218A P186 T216 C217 R218 S221 W241 G242 V243 V244 D245
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t8w, PDBe:6t8w, PDBj:6t8w
PDBsum6t8w
PubMed32073845
UniProtP00751|CFAB_HUMAN Complement factor B (Gene Name=CFB)

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