Structure of PDB 6rav Chain BBB

Receptor sequence
>6ravBBB (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
SLCGMVWDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVD
DKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIK
LKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKAL
FVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFL
CTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCVPAHAR
DFHINLFQVLPWLKEKLQDEDLGFL
3D structure
PDB6rav Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
ChainBBB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.47: alternative-complement-pathway C3/C5 convertase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JGQ BBB H57 E97I Y99 P172D Y172F T190 C191 R192 S195 W215 G216 V217 V218 D218A H45 E90 Y92 P183 Y185 T213 C214 R215 S218 W238 G239 V240 V241 D242 BindingDB: Kd=7.9nM,IC50=0.01nM
BS02 ZN BBB D171 H223 D178 H248
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:6rav, PDBe:6rav, PDBj:6rav
PDBsum6rav
PubMed30926668
UniProtP00751|CFAB_HUMAN Complement factor B (Gene Name=CFB)

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