Structure of PDB 6qsx Chain BBB

Receptor sequence
>6qsxBBB (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
SLCGMVWEGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCF
TVDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVA
LIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDI
KALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTP
RFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQ
KRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
3D structure
PDB6qsx Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
ChainBBB
Resolution1.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.47: alternative-complement-pathway C3/C5 convertase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JGN BBB A172C P172D Y172F T190 C191 R192 S195 W215 G216 V218 D218A A185 P186 Y188 T216 C217 R218 S221 W241 G242 V244 D245 BindingDB: IC50=3350nM
BS02 ZN BBB D171 H223 D181 H259
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qsx, PDBe:6qsx, PDBj:6qsx
PDBsum6qsx
PubMed30926668
UniProtP00751|CFAB_HUMAN Complement factor B (Gene Name=CFB)

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