Structure of PDB 6qsw Chain BBB

Receptor sequence
>6qswBBB (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
LSLCGMVWDYHKQPWQAKISVIGHESCMGAVVSEYFVLTAAHCFTVDDKE
HSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKN
KLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVS
EELTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVS
PYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCVPAHARDFHINL
FQVLPWLKEKLQDEDLGFL
3D structure
PDB6qsw Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
ChainBBB
Resolution1.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.47: alternative-complement-pathway C3/C5 convertase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JGT BBB Y99 P172D Y172F R192 S214 W215 G216 V217 V218 Y89 P177 Y179 R209 S231 W232 G233 V234 V235 BindingDB: IC50=6600nM,Kd=10000nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qsw, PDBe:6qsw, PDBj:6qsw
PDBsum6qsw
PubMed30926668
UniProtP00751|CFAB_HUMAN Complement factor B (Gene Name=CFB)

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