Structure of PDB 5t0c Chain BB

Receptor sequence
>5t0cBB (length=341) Species: 9606 (Homo sapiens) [Search protein sequence]
EEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKD
LLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDN
QIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQ
TSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGT
KRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALI
RPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSG
ADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEG
3D structure
PDB5t0c Structural basis for dynamic regulation of the human 26S proteasome.
ChainBB
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP BB I187 G229 T230 G231 K232 T233 I364 S391 G392 A393 I95 G137 T138 G139 K140 T141 I272 S299 G300 A301
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005838 proteasome regulatory particle
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5t0c, PDBe:5t0c, PDBj:5t0c
PDBsum5t0c
PubMed27791164
UniProtP62191|PRS4_HUMAN 26S proteasome regulatory subunit 4 (Gene Name=PSMC1)

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