Structure of PDB 7q8h Chain BA

Receptor sequence
>7q8hBA (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
LPKSVDWRKKGYVTPVKNQKQCGSAWAFSATGALEGQMFRKTGKLVSLSE
QNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKY
RPENSVAQDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSG
IYFEPDCSSKNLDHGVLVVGYGFEGANSQNSKYWLVKNSWGPEWGSNGYV
KIAKDKNNHCGIATAASYPNV
3D structure
PDB7q8h Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins.
ChainBA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.43: cathepsin V.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide BA G244 A246 W247 Q284 N287 G288 G289 F290 N382 L383 D384 G23 A25 W26 Q63 N66 G67 G68 F69 N161 L162 D163
BS02 TFA BA F290 M291 A292 A436 F69 M70 A71 A215
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7q8h, PDBe:7q8h, PDBj:7q8h
PDBsum7q8h
PubMed37095140
UniProtO60911|CATL2_HUMAN Cathepsin L2 (Gene Name=CTSV)

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