Structure of PDB 7q8g Chain BA

Receptor sequence
>7q8gBA (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
LPKSVDWRKKGYVTPVKNQKQCGSSWAFSATGALEGQMFRKTGKLVSLSE
QNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKY
RPENSVAQDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSG
IYFEPDCSSKNLDHGVLVVGYGFEGANSQNSKYWLVKNSWGPEWGSNGYV
KIAKDKNNHCGIATAASYPNV
3D structure
PDB7q8g Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins.
ChainBA
Resolution2.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.43: cathepsin V.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide BA G245 S247 Q285 G289 G290 F291 M292 A358 D385 H386 G23 S25 Q63 G67 G68 F69 M70 A136 D163 H164
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7q8g, PDBe:7q8g, PDBj:7q8g
PDBsum7q8g
PubMed37095140
UniProtO60911|CATL2_HUMAN Cathepsin L2 (Gene Name=CTSV)

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