Structure of PDB 6tb3 Chain BA

Receptor sequence

>6tb3BA (length=386) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

SHRKYEAPRHGHLGFLPRKRAASIRARVKAFPKDDRSKPVALTSFLGYKA
GMTTIVRDLDRPGSKFHKREVVEAVTVVDTPPVVVVGVVGYVETPRGLRS
LTTVWAEHLSDEVKRRFYKNWYKSKKKAFTKYSAKYAQDGAGIERELARI
KKYASVVRVLVHTQIRKTPLAQKKAHLAEIQLNGGSISEKVDWAREHFEK
TVAVDSVFEQNEMIDAIAVTKGHGFEGVTHRWGTKKLPRKTHRGLRKVAC
IGAWHPAHVMWSVARAGQRGYHSRTSINHKIYRVGKGDDEANGATSFDRT
KKTITPMGGFVHYGEIKNDFIMVKGCIPGNRKRIVTLRKSLYTNTSRKAL
EEVSLKWIDTASKFGKGRFQTPAEKHAFMGTLKKDL

3D structure

PDB

6tb3 The Ccr4-Not complex monitors the translating ribosome for codon optimality.

Chain

Resolution

2.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	BA	S2 H3 R4 K5 E7 A8 P9 R10 H11 G12 H13 L14 G15 L17 P18 R19 K20 R21 R26 R28 K30 A31 M53 T54 T55 R62 S65 A75 Y92 T95 R97 L99 R100 S101 L102 T103 T104 W106 R116 R117 F118 Y119 K120 N121 Y123 K124 S125 K126 K128 F130 K132 Y133 R150 K153 Y154 R159 Q173 K174 K175 E180 T221 K222 G223 H224 G225 F226 G228 H231 R232 K236 K237 R240 K241 T242 H243 R244 G245 L246 R247 K248 A250 C251 I252 G253 A254 W255 H256 A258 H259 V260 M261 W262 S263 R266 A267 Q269 R270 Y272 S274 R275 T276 I278 N279 G309 H313 K325 C327 I328 P329 G330 N331 R332 K333 R334 R339 L342 Y343 R348 S363 K364 F365 G366 K367 K376 M380 K384 K385	S1 H2 R3 K4 E6 A7 P8 R9 H10 G11 H12 L13 G14 L16 P17 R18 K19 R20 R25 R27 K29 A30 M52 T53 T54 R61 S64 A74 Y91 T94 R96 L98 R99 S100 L101 T102 T103 W105 R115 R116 F117 Y118 K119 N120 Y122 K123 S124 K125 K127 F129 K131 Y132 R149 K152 Y153 R158 Q172 K173 K174 E179 T220 K221 G222 H223 G224 F225 G227 H230 R231 K235 K236 R239 K240 T241 H242 R243 G244 L245 R246 K247 A249 C250 I251 G252 A253 W254 H255 A257 H258 V259 M260 W261 S262 R265 A266 Q268 R269 Y271 S273 R274 T275 I277 N278 G308 H312 K324 C326 I327 P328 G329 N330 R331 K332 R333 R338 L341 Y342 R347 S362 K363 F364 G365 K366 K375 M379 K383 K384
BS02	MG	BA	S2 H3	S1 H2

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006414	translational elongation
GO:1990145	maintenance of translational fidelity

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6tb3, PDBe:6tb3, PDBj:6tb3
PDBsum	6tb3
PubMed	32299921
UniProt	P14126\|RL3_YEAST Large ribosomal subunit protein uL3 (Gene Name=RPL3)

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