Structure of PDB 5t0c Chain BA

Receptor sequence
>5t0cBA (length=361) Species: 9606 (Homo sapiens) [Search protein sequence]
APPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFV
VDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDV
TYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGK
TLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLI
FFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATN
RPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFEL
LARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAK
FSATPRYMTYN
3D structure
PDB5t0c Structural basis for dynamic regulation of the human 26S proteasome.
ChainBA
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP BA G178 P218 T220 G221 K222 T223 G382 A383 G106 P146 T148 G149 K150 T151 G310 A311
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0001649 osteoblast differentiation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0000932 P-body
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex
GO:0034774 secretory granule lumen
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5t0c, PDBe:5t0c, PDBj:5t0c
PDBsum5t0c
PubMed27791164
UniProtP35998|PRS7_HUMAN 26S proteasome regulatory subunit 7 (Gene Name=PSMC2)

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