Structure of PDB 8rm5 Chain B1

Receptor sequence
>8rm5B1 (length=870) Species: 9606 (Homo sapiens) [Search protein sequence]
ERNRPLSDEELDAMFPEGYKVLNDQPSGNLPFLKPDDIQYFDKLLVDVDE
STLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQ
ILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLID
EDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAV
VASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLR
SLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWKG
IRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEM
KKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLV
DTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADI
DHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICG
TVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGE
EYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQEN
CIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYI
AKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMN
EYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVH
RQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGAL
EGLRVAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHY
PRIYNDDKNTYIRYELDYIL
3D structure
PDB8rm5 Structural insights into the cross-exon to cross-intron spliceosome switch
ChainB1
Resolution6.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B1 R1074 Q1104 R640 Q670
BS02 rna B1 E1064 A1068 H1069 S1223 P1224 P1257 A1258 R1259 E630 A634 H635 S789 P790 P823 A824 R825
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:1990935 splicing factor binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006338 chromatin remodeling
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0034693 U11/U12 snRNP
GO:0071004 U2-type prespliceosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0110016 B-WICH complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rm5, PDBe:8rm5, PDBj:8rm5
PDBsum8rm5
PubMed38778104
UniProtO75533|SF3B1_HUMAN Splicing factor 3B subunit 1 (Gene Name=SF3B1)

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