Structure of PDB 9f37 Chain B

Receptor sequence

>9f37B (length=736) Species: 11320 (Influenza A virus)

MDVNPMLIFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVIRTHDYS
SRGIWKTNSETGAQQLNPIDGPLPEDNEPSGYAQTDCVLELIEGLDRSHP
GLFETACQETIDAIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RKNGYKLNESGRLIDFLKDVLLSFENDSMEVTTHFGKKRVKLTKKNYLIR
ALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVELLARNICERLEQSG
LPVGGNEKKAKLANVIKKMMAKSTDEELSYTITGDNTKWNENQNPRIFLA
MVLRITAGQPEWFRDLLAVAPIMFSNKVARLGRGYMFESKSMHLRTQISA
ENLSDINLRYFNEDTKKKIEKIRHLMVEGTASLSPGMMMGMFNMLSTVLG
VSVLNLGQREILKRTYWWDGLQSSDDFALIINGHFKEDIQQGVNHFYRTC
KLVGINMSQKKSYINKTGTFEFTSFFYRYGFVANFSMELPSFGVAGNNES
ADMSIGTTVIKTNMINNDLGPATAQMAIQLFIKDYRYTYRCHRGDTNLET
RRTKSIKRLWTETISKAGLLVADGGPNPYNLRNLHIPEVCLKWSLMDPDY
RGRLCNPNNPFVHHMEVESTNLAVVMPAHGPAKSLEYDAVATTHSWTPKR
NRSILNTNQRGILEDERIYQKCCQVFEKFFPSSTYRRPIGMASMLDAMLS
RARIDARIDLESGRISSQDFSEITNTCKAIEALKRQ

3D structure

• PDB: 9f37 High-resolution structure of a replication-initiation like configuration of influenza polymerase active site visualises the essential role of a conserved dibasic motif in the PA subunit
• Chain: B
• Resolution: 1.905 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	G125 R126 Q127 R135 N136 K229 D230 I241 A242 T243 R249 R353 M409 G410 N413 P651 N671 R672 S673 I674 N676	G125 R126 Q127 R135 N136 K209 D210 I221 A222 T223 R229 R333 M389 G390 N393 P631 N651 R652 S653 I654 N656
BS02	rna	B	H32 T34 Y38 M356 R365	H32 T34 Y38 M336 R345
BS03	CTP	B	R239 D305 N306 T307 K308 W309 N310 M409 G410 D445 K481	R219 D285 N286 T287 K288 W289 N290 M389 G390 D425 K461
BS04	GTP	B	N413 D446 T493 S494 H649 G650	N393 D426 T473 S474 H629 G630
BS05	MG	B	D305 D445 D446	D285 D425 D426
BS06	MG	B	D305 N306 D445	D285 N286 D425

External links

• PDB: RCSB:9f37, PDBe:9f37, PDBj:9f37
• PDBsum: 9f37
• UniProt: H6QM91