Structure of PDB 9exw Chain B

Receptor sequence
>9exwB (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
LKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKSARQYHVQFFGDAP
ERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGKLRAQ
WEMGIVQAEEAASMSVEERKAKFTF
3D structure
PDB9exw Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches.
ChainB
Resolution2.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.357: [histone H3]-lysine(36) N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1H7X B K317 A320 K96 A99
BS02 A1H7X B V230 Y233 W236 F266 F267 G268 A270 E272 L318 Q321 V13 Y16 W19 F45 F46 G47 A49 E51 L97 Q100
External links
PDB RCSB:9exw, PDBe:9exw, PDBj:9exw
PDBsum9exw
PubMed38748070
UniProtO96028|NSD2_HUMAN Histone-lysine N-methyltransferase NSD2 (Gene Name=NSD2)

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